Manager Graham Alexander will be hoping his side can make it to the third round stage by seeing off the Foxes at Glanford Park.
Leicester got through a group including Carlisle United, Fleetwood Town and Morecambe to get to this round.
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Alexander says there will be changes from the side that faced Doncaster Rovers in the second round of the FA Cup on Sunday.
That could mean a chance for players who were on the bench at the Keepmoat Stadium to start and try to impress their way into the starting XI.
The Iron will be without right-back Jordan Clarke (hamstring), who will be out for the next fortnight at least.
Meanwhile, Lee Novak (ankle) will also be out for two weeks after limping off injured at Bradford City.
Meanwhile, Sam Mantom (groin), Luke Williams (hamstring) and Jonathon Margetts (knee) will continue to miss out.
